Dental implants have become an important treatment for the replacement of teeth lost due to disease, injury, or congenital tooth agenesis (Adell et al. 1990). Over the past 30 years, the incorporation of dental implants into everyday clinical dental practice has resulted in major improvements in oral health of our patients through enhancements in function, esthetics, and phonetics. In this month’s issue of the Journal, we highlight new evidence on the biological complications of dental implants and the great challenges associated with predictable implant therapy.